Sign Out
Early signs of toxicity with Methotrexate include leucopenia, thrombocytopenia, anaemia, ulceration of the mouth, and gastro-intestinal effects, stomatitis or diarrhoea are signs that treatment should be interrupted, otherwise haemorrhagic enteritis and intestinal perforation may follow. Bone-marrow depression may occur abruptly; megaloblastic anaemia has been reported. Methotrexate is immunosuppressant and hypogammaglobulinaemia may occur. Liver damage has been reported, especially in patients given high-dose therapy or long-term treatment; it may occur in the absence of other signs of Methotrexate toxicity. Kidney damage, osteoporosis, effects on skin and nails, and pulmonary reactions, including interstitial pneumonitis, have developed.
Fatalities have occurred. Methotrexate may cause defective oogenesis and spermatogenesis, and fertility may be impaired. Metabolic alterations, including precipitation of diabetes, have been reported. Neurotoxic reactions may occur, especially after the intrathecal use of Methotrexate. Teratogenic effects and foetal deaths have been reported.
